Clinical Podcasts

UpToDate faculty discuss important “What’s New” and “Practice Changing UpDates”, based on recent medical journal articles, in our clinical podcasts. Our contributors are recognized physician leaders in their fields and offer their expertise regarding each update and its impact on clinical practice. Each clinical podcast includes the most current clinical information available as of the release date listed.

Support for UpToDate Talk is provided by UpToDate, Wolters Kluwer. UpToDate is entirely funded by the subscriptions of its users and does not accept advertising or funding unrelated to subscriptions. The opinions in such podcasts are entirely those of the discussants, and these discussants are authors and editors for UpToDate. View the UpToDate conflict of interest policy.

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Edaravone for amyotrophic lateral sclerosis; Neonatal mortality in US planned home births

Date Released: Aug 9 2017

This episode features Dr. Jeremy Shefner, discussing the use of edaravone for the treatment of amyotrophic lateral sclerosis, and Dr. Charles Lockwood, discussing neonatal mortality in planned home births. Dr. Helen Hollingsworth hosts.

Dr. ShefnerDr. Jeremy Shefner is Professor and Chair of Neurology at the Barrow Neurological Institute, Professor of Neurology at the University of Arizona in Phoenix, and Clinical Professor of Neurology at Creighton University.
Dr. LockwoodDr. Charles Lockwood is Professor of Obstetrics and Gynecology at the University of South Florida, Dean of the Morsani College of Medicine and Senior Vice President of the University of South Florida Health.

Segment on edaravone for amyotrophic lateral sclerosis (Dr. Jeremy Shefner):

  1. Writing Group, Edaravone (MCI-186) ALS 19 Study Group. Safety and efficacy of edaravone in well defined patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial. Lancet Neurol 2017; 16:505.

Segment on neonatal mortality in US planned home births (Dr. Charles Lockwood):

  1. Grunebaum A, McCullough LB, Sapra KJ, et al. Planned home births: The need for additional contraindications. Am J Obstet Gynecol 2017; 216:401.e1.

Jeremy M Shefner, MD, PhD Grant/Research Support: Biogen Idec; Cytokinetics; Neuraltus [ALS]; Avanir [ALS (Nuedexta)]. Consultant/Advisory Boards: Biogen Idec; Cytokinetics; Ionis; Neuraltus; Mitsubishi Tanabe [ALS]; Edaravone [ALS (MT Pharma)].

Charles J Lockwood, MD, MHCM Consultant/Advisory Boards: Celula [Aneuploidy screening (No current products or drugs in the US)].

Buprenorphine for neonatal abstinence syndrome; Sublingual immunotherapy for house dust mite allergy

Date Released: Jul 26 2017

In this episode, Dr. Lauren Jansson discusses buprenorphine for neonatal abstinence syndrome, and Dr. Peter Creticos discusses a sublingual immunotherapy tablet for house dust mite allergies. Dr. Sadhna Vora hosts.

Dr. JanssonDr. Lauren Jansson is an Associate Professor of Pediatrics at the Johns Hopkins University School of Medicine and Director of Pediatrics at the Center for Addiction and Pregnancy.
Dr. CreticosDr. Peter Creticos is an Associate Professor of Medicine at the Johns Hopkins University School of Medicine.

Segment on buprenorphine for neonatal abstinence syndrome (Dr. Jansson):

  1. Kraft WK, Adeniyi-Jones SC, Chervoneva I, et al. Buprenorphine for the Treatment of the Neonatal Abstinence Syndrome. N Engl J Med 2017; 376:2341.

Segment on sublingual immunotherapy tablet for house dust mite allergy (Dr. Creticos):

  1. Nolte H, Bernstein DI, Nelson HS, et al. Efficacy of house dust mite sublingual immunotherapy tablet in North American adolescents and adults in a randomized, placebo-controlled trial. J Allergy Clin Immunol 2016; 138:1631.

Lauren M Jansson MD Nothing to disclose

Peter S Creticos, MD Grant/Research/Clinical Trial Support: Stallergenes-Greer [Immunotherapy (SLIT)]; Circassia [Immunotherapy (Peptides)]. Consultant/Advisory Boards: Circassia; Greer; ITI [Immunotherapy (SCIT; SLIT)]; Allakos [Cytokine antagonists]; ASIT [AIT].

Goal blood pressure in older adults; Dexamethasone and acute pharyngitis pain in adults

Date Released: Jul 12 2017

This episode features Dr. Brent Egan discussing the target blood pressure in older adults, and Dr. Mark Aronson discussing the use of dexamethasone for acute pharyngitis pain in adults. Dr. Nancy Sokol hosts.

Dr. NathanDr. Brent Egan is a Professor of Medicine at the University of South Carolina School of Medicine, and Chief Science Officer at the Care Coordination Institute.
Dr. AronsonDr. Mark Aronson is a Professor of Medicine at Harvard Medical School, Associate Chief of the Division of General Medicine and Primary Care and Vice Chair for Quality at the Beth Israel Deaconess Medical Center in Boston.

Segment on Goal blood pressure in older adults (Dr. Brent Egan):

  1. Bavishi C, Bangalore S, Messerli FH. Outcomes of Intensive Blood Pressure Lowering in Older Hypertensive Patients. J Am Coll Cardiol 2017; 69:486.

Segment on Dexamethasone for acute pharyngitis pain in adults (Dr. Mark Aronson):

  1. Hayward GN, Hay AD, Moore MV, et al. Effect of Oral Dexamethasone Without Immediate Antibiotics vs Placebo on Acute Sore Throat in Adults: A Randomized Clinical Trial. JAMA 2017; 317:1535.

Brent M Egan, MD Grant/Research/Clinical Trial Support: Boehringer [Diabetes (Empagliflozin)]. Speaker's Bureau: Medtronic [Hypertension (Renal artery denervation to lower blood pressure)]; Merck International [Hypertension, heart failure (Bisoprolol)]. Consultant/Advisory Boards: Valencia [Hypertension (Device-based treatment to lower blood pressure)]; Inside Edge Consulting [Clinical trials (Patient recruitment and retention)].

Mark D Aronson, MD Nothing to disclose

Complications of t1 and t2 diabetes diagnosed in childhood; Gene therapy for sickle cell disease

Date Released: Jun 28 2017

Dr. Joseph Wolfsdorf discusses complications related to type 1 and type 2 diabetes in pediatric patients, and Dr. Michael DeBaun discusses a report of gene therapy for sickle cell disease. Dr. Nancy Sokol hosts.

Dr. WolfsdorfDr. Joseph Wolfsdorf is a Professor of Pediatrics at Harvard Medical School, and Director of the Diabetes Program at the Boston Children's Hospital.
Dr. DeBaunDr. Michael DeBaun is a Professor of Pediatrics and Medicine at Vanderbilt University and is Director of the Vanderbilt-Meharry Center for Excellence in Sickle Cell Disease.

Segment on diabetes in children (Dr. Wolfsdorf):

  1. Dabelea D, Stafford JM, Mayer-Davis EJ, et al. Association of Type 1 Diabetes vs Type 2 Diabetes Diagnosed During Childhood and Adolescence With Complications During Teenage Years and Young Adulthood. JAMA 2017; 317:825.

Segment on gene therapy for sickle cell disease (Dr. DeBaun):

  1. Ribeil JA, Hacein-Bey-Abina S, Payen E, et al. Gene Therapy in a Patient with Sickle Cell Disease. N Engl J Med 2017; 376:848.

Joseph I Wolfsdorf, MB, BCh Nothing to disclose

Michael R DeBaun, MD, MPH Nothing to disclose

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